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Discussion Topic #1: Myasthenia Gravis
Answer the following questions for this discussion board assignment:
- What is the problem for patients with MG?
- How does MG impact the normal mechanisms involved in the neuromuscular junction and, eventually, skeletal muscle contraction? **Discuss the the NORMAL mechanism at the NMJ for both neurotransmitter release at the presynaptic motor neuron AND the mechanism for skeletal muscle fiber contraction**
- Based on your understanding of the normal physiology mechanism of skeletal muscle contraction and the pathophysiology of MG, how do treatments using acetylcholinesterase inhibitors help MG patients?
Discussion Topic #1: Myasthenia Gravis Answer
Myasthenia gravis (MG) is a chronic autoiummune disease characterized by the weakness and rapid fatigue of voluntary muscles in the body. This disease, which occurs in 1 out of 20,000 people, is caused by the inability of the neuromuscular junctions to transmit enough signals from the nerve fibers to the muscle fibers caused by the decrease in the number of available acetylcholine receptors (AChRs).