Cell Division Homework

1.    Explain how the synthesis and degradation pathways control cell cycle progression.
2.    What is getting synthesized and degraded? When?
3.    How are Cdks turned on to advance the cell cycle?
4.    Explain the role of kinases and phosphatases in cell cycle progression? What about in cell cycle arrest?

5.    How does localization of specific proteins lead to regulation of the cell cycle?

6.    What is localized and where is it going?

7.    Map out and explain in your own words each step of the ATR DNA damage checkpoint (steps 1-6 Fig 14.9).

8.    What role does Cdc25 phosphorylation play in the activation of Cdk1?         What role does Cdc25 phosphorylation play in the ATR cell cycle checkpoint? How is it possible that phosphorylation of Cdc25 causes two very different events?

9.    Map out and explain in your own words each step of the ATM DNA damage checkpoint (steps a-f Fig 14.9).

Cell Division Homework Answer